Over the past 18 years, I have developed a research program that focusses on integrative mitochondrial biology. As such, my laboratory has built strong expertise in the analysis of many facets of mitochondria, with the ability to combine detailed mechanistic studies with the analysis of functional repercussions in isolated organelles, permeabilized or intact cells, mouse models of disease, and fibroblasts or muscle biopsies from patients. Beyond bioenergetics and metabolism, our group has actively studied processes such as reactive oxygen species (ROS) metabolism and permeability transition pore opening, as well as mitochondrial quality control mechanisms, such as mitophagy and the shedding of mitochondrial-derived vesicles. In all our work, we successfully merge cutting-edge imaging and molecular techniques with omics and functional analyses to gain valuable insights into the basic biology of these organelles and to better understand their role in the pathophysiology of genetic and acquired diseases.
Professor Burelle is accepting new students for thesis supervision.