All information on employment opportunities for faculty, students, postdoctoral fellows, and research personnel, can be found here.
New and Renewal of Appointments: Cross-Appointments and Adjunct Memberships
You wish to apply or renew a Cross-Appointment or an Adjunct membership with the Department of Cellular and Molecular Medicine? Please do not hesitate to communicate with Gina Campbell at [email protected] for further information.
A 1-year contract Research Technician position is available in the Ferguson laboratory at the University of Ottawa’s department of Cellular and Molecular Medicine, located at Roger Guindon Hall. Start date: September 1, 2022.
Dr. Ferguson’s laboratory is interested in the regulation of G protein-coupled receptor (GPCR) signaling. The laboratory studies the molecular mechanisms underlying the signaling, endocytosis and recycling of GPCRs and how this regulates the cell biology of GPCR function in cell culture as well as animal models of disease. The focus of the laboratory is on Alzheimer’s and Huntington’s disease, stress and anxiety and hypertension and involves the study of glutamate, CRF and angiotensin receptors.
The position will involve: Essential to the position will be skill demonstrated in mouse genotyping by PCR, breeding, genetic crossing and mouse colony maintenance as well as lab management, ordering and data analysis and record keeping. Additional experience with cell culture, molecular biological techniques, site directed mutagenesis, siRNA, CRISPR/Cas9, SDS PAGE, immunoblot, immunohistochemistry, and ELISA would be beneficial to the candidate. The successful candidate will be expected to work in coordination with the PI to facilitate the research and graduate students and postdoctoral fellows in the laboratory. The candidate requires a strong work ethic and enthusiasm to work independently while being part of a research team.
Knowledge of basic science and biological sciences
Extensive molecular biology expertise
Experience with mammalian cell culture
High proficiency computer skills
Ability to balance multiple priorities
Preferably a M.Sc. degree or a minimum of a Bachelor degree and two years related experience, or relevant experience in lieu of education
Excellent oral and written communication skills in English
This position is a 12-month contract. Salary: A competitive package of salary and benefits will be offered to the successful candidate based on qualifications and experience.
Please send resume, brief statement of research experience and career goals, and the telephone number and email addresses of three (3) references to Dr. Stephen Ferguson
A postdoctoral fellow position is available in the laboratory of Dr. Nongnuj Tanphaichitr, Ottawa Hospital Research Institute (OHRI), to carry out a new research project. In this study, the candidate will develop dosage formulation (delivery system) of antimicrobial peptides (AMPs) to be administered intravaginally. We will focus on the cathelicidin AMP, LL-37, and its derived peptide, 17BIPHE2, which possess both spermicidal and microbicidal activity (Kiattiburut et al., Human Reprod 2018, 33:2175-2183). As Multipurpose Prevention Technology (MPT) agents, these AMPs will provide women with empowerment to protect themselves against unwanted pregnancies and sexually transmitted infections. This study is funded by Canadian Institutes of Health Research (CIHR) and is being carried out in both mouse (in vitro and in vivo) and human (in vitro and ex vivo) systems.
Candidates must have a Ph.D. in biochemistry, cell biology/physiology or related biomedical fields with ability to communicate well at both oral and written levels. Knowledge and lab experience in the female reproductive physiology, sperm biology, and hydrogel and/or nanoparticles-based drug delivery to the vagina will give priorities in the recruitment. Self-motivation to progress in his/her career as an independent investigator will also be favorably considered.
Salary and benefits will be commensurate with the candidate’s experience, following the guideline of OHRI. The term of employment can be up to 4 years. OHRI is one of the foremost Canadian hospital-based research institutes with investigators performing research focusing on answering important health questions and translating their findings into benefits for mankind. A sizable group of researchers in the field of reproductive biology are members of OHRI and also other academic institutes in Ottawa.
Please send your CV with description of research experience and names of three references to [email protected]
An MSc position is open in the Tóth lab to conduct structure-function studies on a newly discovered cellular organelle (Anastasia et al. Cell Reports, 2021). The candidate will learn to use state-of-the-art imaging methodologies such as electron tomography to reconstruct the various compartments of the cell in 3D. In addition, they will learn how to design, test, and analyze quantitative electron microscopy data and present them to both scientific and external audiences. Through this research program, the candidate will learn to recognize, evaluate, and solve any complex problem using the scientific method. The student will be part of a highly dynamic and collaborative project.
Postdoctoral positions are available in the laboratory of Dr. Xiaohui Zha at Ottawa Hospital Research Institute/University of Ottawa, Canada
The project is to study the mechanisms by which cholesterol regulates macrophage inflammation, a key event in atherosclerosis. Cholesterol, a major component of the plasma membrane in mammalian cells, predominantly regulates membrane physical properties. Most likely through its modulation of cellular membranes, cholesterol impacts numerous signal transduction pathways and cellular processes. Particularly, cholesterol levels in macrophages determine the nature of the inflammation response, for example, pro-inflammatory response (M1), anti-inflammatory (M2) or anything in between. The mechanism is largely unknown. In recent years, it is increasingly apparent that macrophages can respond to environmental cues to establish an epigenetically “poised” state. This allows macrophages to rapidly launch a large-scale gene expression program upon stimulation (i.e. LPS). The project will use biochemistry and genomic techniques, such as RNA-seq and ChIP-seq, to understand how cholesterol establishes epigenetically “poised” states in the genome of the macrophages to regulate gene expression for inflammatory responses.
Candidates should be a fresh PhD (less than two years since graduation) in physical science or biological science with good publication record. Knowledge/experience in genomic system biology is a plus, but not necessary. If interested, please send curriculum vitae and brief statement of research interest to [email protected]
Xiaohui Zha, Senior Scientist
Chronic Disease Program
Ottawa Hospital Research Institute
501 Smyth Road, Ottawa, ON K1H 8L6